Peer-reviewed veterinary case report
Development of Two Mouse Models for Vaccine Evaluation against Cryptosporidiosis.
- Journal:
- Infection and immunity
- Year:
- 2022
- Authors:
- Dayao, Denise Ann et al.
- Affiliation:
- Department of Infectious Disease and Global Health · United States
Abstract
Cryptosporidiosis was shown a decade ago to be a major contributor to morbidity and mortality of diarrheal disease in children in low-income countries. A serious obstacle to develop and evaluate immunogens and vaccines to control this disease is the lack of well-characterized immunocompetent rodent models. Here, we optimized and compared two mouse models for the evaluation of vaccines: the Cryptosporidium tyzzeri model, which is convenient for screening large numbers of potential mixtures of immunogens, and the Cryptosporidium parvum-infected mouse pretreated with interferon gamma-neutralizing monoclonal antibody.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/35735982/