Peer-reviewed veterinary case report
Dog diagnosed with rare CD30 positive lymphoma and poor outcome
By Pittaway, Rachel et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2018·The Royal Veterinary College, United Kingdom·View original on PubMed →
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Original publication title: Diagnosis of anaplastic large-cell lymphoma in a dog using CD30 immunohistochemistry.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog was diagnosed with a type of cancer called anaplastic large-cell lymphoma after tests showed that the cancer cells did not express common markers for B- or T-lymphocytes, but did test positive for CD30. Unfortunately, the dog passed away five months after the diagnosis, indicating a poor prognosis for this type of lymphoma. This case highlights the need for more research on similar cases in dogs to better understand this cancer and explore potential treatments targeting CD30.
People also search for: dog lymphoma symptoms · anaplastic large-cell lymphoma in dogs · CD30 treatment for dog cancer
Abstract
Anaplastic large-cell lymphoma or null-cell lymphoma is a clinical entity reported in people, classified according to the unique appearance of large pleomorphic cells that express CD30. Null-cell lymphoma has also been described in dogs when neither CD3 nor CD79α is expressed by the tumor. We describe a case of lymphoma in the dog in which neoplastic cells did not express routine B- or T-lymphocyte markers on flow cytometry or immunohistochemistry; however, cells immunohistochemically labeled for CD30. The dog in our case died 5 mo after initial presentation, confirming a poor prognosis. Identification of further similar cases in dogs would provide additional prognostic information for this subset of lymphomas. CD30 may also serve as a potential therapeutic target in anaplastic large-cell lymphomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29455626/