Peer-reviewed veterinary case report
Cat diagnosed with kidney lymphoma using urine cell stain test
By Reinhart, Brodie et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2024·Department of Pathology and Microbiology·View original on PubMed →
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Original publication title: Diagnosis of renal lymphoma by Wright-Giemsa-stained cytocentrifuged urine evaluation in a cat.
- Species:
- cat
Plain-English summary
A 15-year-old female domestic shorthair cat was brought in because she was losing weight and drinking and urinating more than usual. Tests showed she had anemia and kidney problems, and a special urine test revealed a large number of abnormal lymphocytes, which are a type of white blood cell. Unfortunately, the cat was diagnosed with T-cell renal lymphoma, a type of cancer affecting the kidneys, and she was euthanized. This case highlights how examining urine can help diagnose lymphoma in cats.
People also search for: cat weight loss and increased thirst · cat kidney cancer symptoms · how to diagnose lymphoma in cats
Abstract
Lymphoma represents up to 30% of neoplasms diagnosed in cats. Diagnosis of lymphoma in the urinary system by examination of urine sediment has been described in a dog, but apparently not previously in cats. Concurrent samples of serum, EDTA whole blood, and urine were submitted from a 15-year-old spayed female domestic shorthair cat exhibiting weight loss, polyuria, and polydipsia. Hematology and biochemical abnormalities included a mild normocytic, normochromic, non-regenerative anemia; an inflammatory leukogram; and azotemia. Urinalysis evaluation revealed inadequate urine concentration and marked proteinuria. Wet-mount urine sediment examination revealed moderate numbers of leukocytes and erythrocytes. A uniform population of intermediate-to-large lymphocytes was observed on a fresh, Wright-Giemsa-stained preparation from cytocentrifuged urine. The cat was euthanized and necropsy was completed. Bilateral renomegaly was identified and characterized by multifocal, pale-yellow, coalescing, poorly defined, homogenous nodules. Microscopically, these nodules were composed of dense sheets of CD3-positive round cells, consistent with T-cell renal lymphoma. Key clinical message: Lymphoma is a common neoplasm in cats that can affect many organ systems, including the upper urinary tract. This case represents an uncommon method of identifying neoplastic lymphocytesevaluation of cytocentrifuged urine, and emphasizes the benefits of examining Romanowsky-stained urine sediment in animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38827601/