Peer-reviewed veterinary case report
How well ultrasound finds liver and spleen lymphoma in dogs and cats
By Sumping, J C et al.·Published in The Journal of small animal practice·2022·Small Animal Teaching Hospital, United Kingdom·View original on PubMed →
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Original publication title: Diagnostic accuracy of ultrasonography to detect hepatic and splenic lymphomatous infiltration in dogs and cats.
- Species:
- dog
Plain-English summary
A group of 132 dogs and 29 cats with lymphoma underwent ultrasound exams to check for cancer in their liver and spleen. The results showed that while ultrasound was good at confirming when there was no cancer, it wasn't very effective at detecting it when it was present. In dogs, a specific pattern called leopard-spotted splenic parenchyma was linked to lymphomatous infiltration and could indicate a certain type of lymphoma. This means that while ultrasound can help in some cases, it may not always be reliable for diagnosing lymphoma in these organs.
People also search for: dog lymphoma symptoms · ultrasound liver spleen cancer dog · leopard-spotted spleen dog lymphoma
Abstract
OBJECTIVES: To determine the diagnostic accuracy of ultrasonography in the detection of lymphomatous infiltration of the liver and spleen in a population of dogs and cats with lymphoma. To determine if specific ultrasonographic features of the liver and spleen in dogs are associated with lymphomatous infiltration or a specific immunophenotype of multi-centric lymphoma. MATERIALS AND METHODS: A blinded retrospective evaluation of ultrasonographic images of the liver and/or spleen in dogs and cats with cytologically or histologically confirmed lymphoma was performed by two board-certified veterinary radiologists. RESULTS: A total of 161 animals met the inclusion criteria, comprising 132 dogs and 29 cats. Ultrasonography had a sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 16.7%, 91.0%, 55.9%, 62.5% and 55.0% for the detection of lymphomatous infiltration of the liver, and 73.1%, 93.9%, 82.6%, 93.4% and 74.7% for the spleen. In dogs, an ultrasonographically normal liver was associated with not having lymphomatous infiltration, leopard-spotted splenic parenchyma and splenomegaly were independently associated with lymphomatous infiltration and leopard-spotted splenic parenchyma was also associated with the B cell immunophenotype of multi-centric lymphoma. CLINICAL SIGNIFICANCE: Ultrasonography of the spleen and liver is specific but not sensitive in the detection of lymphomatous infiltration. A leopard-spotted splenic parenchyma in dogs is highly specific for lymphomatous infiltration and in this population predicted a specific immunophenotype of multi-centric lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34617607/