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Peer-reviewed veterinary case report

Diagnostic and vaccine chapter.

Journal:
Vaccine
Year:
2010
Authors:
Wolfram, J H et al.
Affiliation:
CRDF Technical Consultant · United States

Abstract

The first report in this chapter describes the development of a killed composite vaccine. This killed vaccine is non-infectious to humans, other animals, and the environment. The vaccine has low reactivity, is non-abortive, and does not induce pathomorphological alterations to the organs of vaccinated animals. The second report of this chapter describes the diagnostic value of a competitive enzyme-linked immunosorbent assay for detecting Brucella-specific antibodies and its ability to discriminate vaccinated cattle from infected cattle. The results indicated that the competitive enzyme-linked immunosorbent assay is more sensitive than traditional tests for detecting antibodies to Brucella abortus in naturally and experimentally infected cattle.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/20850688/