Peer-reviewed veterinary case report
English Bulldog with spleen disease and swollen belly
By Rodgers, Morwenna et al.·Published in Journal of comparative pathology·2025·Department of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: Diagnostic challenges of polyclonal B-cell lymphocytosis in an English Bulldog (PBLEB) and outcome following splenectomy.
- Species:
- dog
Plain-English summary
A 5-year-old English Bulldog was brought in with a swollen belly and gastrointestinal issues due to a condition called polyclonal B-cell lymphocytosis (PBLEB), which caused an enlarged spleen and high levels of certain proteins in the blood. The dog's symptoms were challenging to diagnose because they can resemble other serious diseases. After thorough testing, the veterinarian decided to remove the spleen, and the dog showed a positive recovery after the surgery.
People also search for: English Bulldog swollen belly · dog splenectomy recovery · polyclonal B-cell lymphocytosis treatment
Abstract
Polyclonal B-cell lymphocytosis of English Bulldogs (PBLEB) is a lymphoproliferative disorder associated with splenomegaly and hyperglobulinaemia. Information regarding both the degree of expected lymphocytic organ infiltration and possible treatment protocols is limited, and clinical overlap with neoplastic lymphoproliferative disease presents a diagnostic challenge. Here, we report and discuss the case of a 5-year-old English Bulldog with PBLEB, presenting with a marked gammopathy, marked splenomegaly and subsequent abdominal distension resulting in gastrointestinal clinical signs. We present extensive clinicopathological and histopathological data, demonstrate marked infiltration of tissues including the bone marrow, and document a favourable clinical outcome following splenectomy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41205250/