Peer-reviewed veterinary case report
Different chromosome changes found in two dogs with similar leukemia
By Nolte, M et al.·Published in Journal of comparative pathology·1993·Pathologisches Institut der Medizinischen Hochschule Hannover, Germany·View original on PubMed →
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Original publication title: Different cytogenetic findings in two clinically similar leukaemic dogs.
- Species:
- dog
Plain-English summary
A 4-month-old German Shepherd puppy and a 7-year-old Boxer were both diagnosed with acute lymphoblastic leukemia, a type of blood cancer. The puppy had a normal set of chromosomes, while the Boxer had an extra chromosome due to a genetic change. These findings suggest that different types of leukemia may occur in dogs at different ages and can be identified through genetic testing. It's important for pet owners to be aware of these differences when seeking treatment options for their dogs.
People also search for: dog leukemia symptoms · German Shepherd puppy cancer · Boxer dog blood cancer treatment
Abstract
A 4-month-old German Shepherd puppy and a 7-year-old Boxer dog, in which a clinical diagnosis of acute lymphoblastic leukaemia had been made, were investigated cytogenetically. In the puppy a diploid karyotype was found, but the malignant clone in the Boxer was characterized by an extra metacentric chromosome, apparently formed as the result of a Robertsonian translocation of two chromosomes 1. These findings are discussed against the background of similar cases reported in the literature. Possibly, different types of acute canine leukaemic disease, occurring at different ages, can be distinguished by cytogenetic evaluation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8366201/