Peer-reviewed veterinary case report
Different roles of the two high-oxygen-affinity terminal oxidases of Brucella suis: Cytochrome c oxidase, but not ubiquinol oxidase, is required for persistence in mice.
- Journal:
- Infection and immunity
- Year:
- 2007
- Authors:
- Jiménez de Bagüés, Maria Pilar et al.
- Affiliation:
- Institut National de la Santé · France
- Species:
- rodent
Abstract
The survival of Brucella suis mutant strains in mice demonstrated different roles of the two high-oxygen-affinity terminal oxidases. The cbb3-type cytochrome c oxidase was essential for chronic infection in oxygen-deficient organs. Lack of the cytochrome bd ubiquinol oxidase led to hypervirulence of bacteria, which could rely on nitrite accumulation inhibiting the inducible nitric oxide synthase of the host.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17101669/