Peer-reviewed veterinary case report
Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection.
- Journal:
- Infection and immunity
- Year:
- 2006
- Authors:
- Loisel-Meyer, Séverine et al.
- Affiliation:
- INSERM U431 · France
- Species:
- rodent
Abstract
A mutant of Brucella suis bearing a Tn5 insertion in norD, the last gene of the operon norEFCBQD, encoding nitric oxide reductase, was unable to survive under anaerobic denitrifying conditions. The norD strain exhibited attenuated multiplication within nitric oxide-producing murine macrophages and rapid elimination in mice, hence demonstrating that norD is essential for Brucella virulence.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16495577/