Peer-reviewed veterinary case report
Differentiation of spontaneous and induced mammary adenocarcinomas of the rat by gene expression profiling.
- Journal:
- Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
- Year:
- 2006
- Authors:
- Marxfeld, Heike et al.
- Affiliation:
- Preclinical Safety
- Species:
- rodent
Abstract
The differentiation of spontaneous and induced adenocarcinomas is of interest in the setting of carcinogenicity studies. In the experiment reported here, a differentiation of morphologically similar spontaneous and induced mammary adenocarcinomas of the rat is achieved by gene expression profiling. By choosing one marker gene based on the gene expression profile for each tumour type, we were able to distinguish the tumours by real-time quantitative polymerase chain reaction (RT-QPCR) as well.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16905300/