Peer-reviewed veterinary case report
Immune changes in dogs after Leishmune vaccine in Brazil
By de Lima, Valéria Marçal Felix et al.·Published in Veterinary immunology and immunopathology·2010·Departamento de Clí, Brazil·View original on PubMed →
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Original publication title: Diminished CD4+/CD25+ T cell and increased IFN-gamma levels occur in dogs vaccinated with Leishmune in an endemic area for visceral leishmaniasis.
- Species:
- dog
Plain-English summary
A group of 20 healthy dogs in Brazil received the Leishmune vaccine to help protect against a serious disease called visceral leishmaniasis. After getting the vaccine, the dogs showed a strong immune response, with all of them producing antibodies against the disease. Additionally, most of the dogs developed cellular immunity, which is important for fighting off infections. The vaccine also changed some immune cell levels, which could be part of how it works. Overall, the Leishmune vaccine appears to be effective in boosting the dogs' defenses against this disease.
People also search for: dog leishmaniasis vaccine · Leishmune vaccine for dogs · canine immune response to vaccines
Abstract
The Leishmune vaccine has been used in endemic areas to prevent canine visceral leishmaniasis in Brazil, but cytokine production induced by vaccination has rarely been investigated in dogs. This study aimed to evaluate the immune response of dogs vaccinated with Leishmune FML vaccine (Fort Dodge) against total antigen of Leishmania (Leishmania) chagasi (TAg) and FML. Twenty healthy dogs from Araçatuba, São Paulo, Brazil, an endemic leishmaniasis area, received three consecutive subcutaneous injection of Leishmune vaccine at 21-day intervals. PBMC were isolated before and 10 days after completing vaccination and lymphoproliferative response and antibody production against FML or total promastigote antigen were tested. Cytokines IFN-gamma, IL-4 and TNF-alpha were measured in culture supernatant and CD4+/CD25+ and CD8+/CD25+ T cell presence was determined. Analysis of the data indicated that the vaccine conferred humoral responses (100%) against both antigens and cellular immunity to FML (85%) and total antigen (80%), the supernatant of cultured cells stimulated with TAg and FML showed an increase in IFN-gamma (P<0.05), and the vaccine reduced CD4+/CD25+ T cell presence compared to that observed before vaccination. These responses may constitute part of the immune mechanism induced by Leishmune.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20132994/