Dirofilaria immitis and Trypanosoma cruzi natural co-infection in dogs.

Abstract

Dirofilariasis (Dirofilaria immitis) and American trypanosomiasis (Trypanosoma cruzi) are zoonotic parasitic diseases affecting the hearts of a variety of mammalian host species, including dogs. In this study, some of the immunopathological characteristics of natural co-infection by these two parasites were compared with T. cruzi infection in dogs from Mexico. Antibody analysis in serum indicated significantly lower anti-T. cruzi IgG levels in co-infected dogs (n = 4) compared to those with T. cruzi infection alone (n = 9), together with a somewhat lower IgG2/IgG1 ratio. Cardiac tissue inflammation was limited and focal in co-infected animals whereas T. cruzi infected dogs had extensive and diffuse tissue inflammation. Three out of nine T. cruzi infected dogs and 1/4 of T. cruzi and D. immitis co-infected dogs showed cardiac alterations. The results showed that co-infections may interfere with host responses, and their significant prevalence (4/13 T. cruzi infected dogs) suggests that they should be taken into account by researchers and clinicians.