Peer-reviewed veterinary case report
Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2012
- Authors:
- Odan, Masahide et al.
- Affiliation:
- Shionogi Pharmaceutical Research Center · Japan
Abstract
The discovery of novel CB2 ligands based on the 3-carbamoyl-2-pyridone derivatives by adjusting the size of side chain at 1-, 5- and 6-position is reported. The structure-activity relationship around this template lead to the identification of S-777469 as a selective CB2 receptor agonist, which exhibited the significant inhibition of scratching induced by Compound 48/80 at 1.0 mg/kg po and 10 mg/kg po (55% and 61%, respectively).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22444677/