Peer-reviewed veterinary case report
Diselenides as novel effective fluorescence quenchers to construct a two-photon fluorescent probe for thiols in a mouse stroke model.
- Journal:
- Chemical communications (Cambridge, England)
- Year:
- 2025
- Authors:
- Ma, Tao et al.
- Affiliation:
- State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering · China
Abstract
A fluorescence quenching mechanism using linear diselenides was proposed for the first time through a combination of intramolecular charge transfer (ICT) and Förster resonance energy transfer (FRET). Herein, we synthesized and screened a two-photon fluorescent probe AFC-SeSe, demonstrating a remarkable 300-fold increase in response to glutathione (GSH). Additionally, AFC-SeSe enabled real-time observation of increased thiol levels following treatment within a short timeframe in a mouse model of stroke.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39774747/