Peer-reviewed veterinary case report
DNA damage found in feline injection-site sarcoma tumors
By Kang, S et al.·Published in Veterinary and comparative oncology·2017·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: DNA damage is a feature of feline injection-site sarcoma.
- Species:
- cat
Plain-English summary
A study looked at cats with injection-site sarcoma, a type of cancer that can develop at vaccination sites. Researchers found that DNA damage was present in the tumor tissues of these cats, which might affect how well they respond to chemotherapy. Despite surgery and radiation being common treatments, this type of cancer often comes back. The findings suggest that understanding DNA damage in these tumors could help predict treatment outcomes, but more research is needed to confirm this.
People also search for: cat injection-site sarcoma treatment · feline cancer DNA damage · cat vaccination site tumor prognosis
Abstract
Feline injection-site sarcoma (FISS) is commonly treated with surgery and radiation therapy. Despite aggressive therapy, FISS has a high recurrence rate. The true benefit of adjuvant chemotherapy is not known. DNA damage response mechanisms help protect against genomic instability but can also promote chemoresistance. In order to determine whether DNA damage is a feature of FISS, we evaluated tumour tissues with γH2AX immunohistochemistry. H2AX is phosphorylated to form γH2AX following DNA double strand breaks. Seventeen FISS specimens were evaluated prospectively. DNA damage ranged from 2.18 to33.7%, with a median of 16.2%. Significant differences were noted between cats (P < 0.0001). Mitotic index ranged from 0 to 57 with a median of 13 and did not correlate with γH2AX positivity (P = 0.2). Further studies are needed to determine if γH2AX expression may predict chemosensitivity and have independent value as a prognostic factor.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26781433/