Peer-reviewed veterinary case report
Inflammation signals differ in dogs with bone cancer
By Axiak-Bechtel, Sandra M et al.·Published in Veterinary medicine and science·2019·Department of Veterinary Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Dogs with osteosarcoma have altered pro- and anti-inflammatory cytokine profiles.
- Species:
- dog
Plain-English summary
A group of dogs with osteosarcoma, a type of bone cancer, showed changes in their immune response compared to healthy dogs. Researchers measured specific immune markers in dogs receiving pain relief medication (NSAIDs) and those not receiving it. They found that dogs with osteosarcoma produced more of a certain inflammatory marker (IL-6) when stimulated, but their levels of another marker (TNF) were similar to healthy dogs. This suggests that dogs with osteosarcoma have a different immune profile, which could be important for future treatments. More research is needed to understand how these findings could help in managing the disease.
People also search for: dog osteosarcoma treatment · inflammatory markers in dogs · NSAIDs for dog cancer · immune response in dogs with cancer
Abstract
BACKGROUND: Current advances in immunotherapy are an exciting area of study in canine osteosarcoma (OSA). The objective of this study was to determine the immune response in dogs with osteosarcoma by measuring stimulated leukocyte production of tumor necrosis factor (TNF), interleukin (IL)-6, IL-10 and TNF and IL-6 to IL-10 ratios. METHODS: Whole blood was collected from dogs with osteosarcoma receiving non-steroidal anti-inflammatory drugs (NSAIDs, n = 11), dogs with osteosarcoma not receiving NSAIDs (n = 14) and healthy dogs (n = 5). RESULTS: No difference in TNF production was found among healthy and OSA dogs regardless of NSAID administration following stimulation with lipopolysaccharide (LPS) (p = .410), lipoteichoic acid (LTA) (p = .693) or PBS (p = .120). Leukocyte IL-6 production was greater in all dogs with OSA after stimulation with LPS (p = .015), LTA (p = .014) and PBS (p = .034) with no difference between OSA dogs receiving NSAIDs and those not. No differences in IL-10 were found among healthy controls and dogs with OSA regardless of NSAID use. There was no difference among groups for LPS-stimulated TNF to IL-10 ratios (p = .407). For LTA-stimulated leukocytes, the TNF to IL-10 ratio was lower in dogs with OSA than in healthy dogs (p = .031) with no difference between OSA NSAID dogs compared to OSA non-NSAID dogs (p = .059). No differences were found in LPS (p = .310)- or LTA (p = .265)-stimulated leukocyte IL-6 to IL-10 production ratios among groups. CONCLUSIONS: Dogs with osteosarcoma have an altered pro- and anti-inflammatory immunologic profile compared to healthy dogs regardless of NSAID use. Further study is indicated to determine the potential prognostic and therapeutic implications of these findings.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31374161/