Peer-reviewed veterinary case report
Gold nanoparticle doxorubicin shows promise for feline injection-site
By Zabielska-Koczywąs, Katarzyna et al.·Published in Molecules (Basel, Switzerland)·2017·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Doxorubicin Conjugated to Glutathione Stabilized Gold Nanoparticles (Au-GSH-Dox) as an Effective Therapeutic Agent for Feline Injection-Site Sarcomas-Chick Embryo Chorioallantoic Membrane Study.
- Species:
- cat
Plain-English summary
A study tested a new treatment for cats with injection-site sarcomas, which are aggressive skin tumors that can come back after treatment. Researchers injected a special form of chemotherapy called doxorubicin, combined with gold nanoparticles, directly into the tumors. This method significantly reduced tumor size in the lab, suggesting it could be an effective option for treating these types of cancers in cats. While this research is still in the early stages, it shows promise for improving outcomes for cats with these difficult-to-treat tumors.
People also search for: cat injection-site sarcoma treatment · feline cancer chemotherapy · doxorubicin for cats
Abstract
Feline injection-site sarcomas are malignant skin tumours with a high local recurrence rate, ranging from 14% to 28%. The treatment of feline injection-site sarcomas includes radical surgery, radiotherapy and/or chemotherapy. In our previous study it has been demonstrated that doxorubicin conjugated to glutathione-stabilized gold nanoparticles (Au-GSH-Dox) has higher cytotoxic effects than free doxorubicin for feline fibrosarcoma cell lines with high glycoprotein P activity (FFS1, FFS3). The aim of the present study was to assess the effectiveness of intratumoural injection of Au-GSH-Dox on the growth of tumours from the FFS1 and FFS3 cell lines on chick embryo chorioallantoic membrane. This model has been utilized both in human and veterinary medicine for preclinical oncological studies. The influence of intratumoural injections of Au-GSH-Dox, glutathione-stabilized gold nanoparticles and doxorubicin alone on the Ki-67 proliferation marker was also checked. We demonstrated that the volume ratio of tumours from the FFS1 and FFS3 cell lines was significantly (< 0.01) decreased after a single intratumoural injection of Au-GSH-Dox, which confirms the positive results of in vitro studies and indicates that Au-GSH-Dox may be a potent new therapeutic agent for feline injection-site sarcomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28208720/