Peer-reviewed veterinary case report
How long to use diazepam or propofol for dog seizures
By Cagnotti, Giulia et al.·Published in Frontiers in veterinary science·2023·Department of Veterinary Sciences, Italy·View original on PubMed →
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Original publication title: Duration of constant rate infusion with diazepam or propofol for canine cluster seizures and status epilepticus.
- Species:
- dog
Plain-English summary
A group of 73 dogs experiencing cluster seizures or status epilepticus (a severe type of seizure) were treated with either diazepam or propofol through a constant rate infusion. Some dogs received the treatment for 12 hours, while others were treated for 24 hours. The results showed that there was no significant difference in how well the dogs responded to the treatment or how long they stayed in the hospital, regardless of the duration of the infusion. Both treatment durations were effective in managing the seizures, but the study did not find that a shorter treatment time led to better outcomes.
People also search for: dog cluster seizures treatment · status epilepticus in dogs · diazepam vs propofol for seizures
Abstract
INTRODUCTION: Constant rate infusion (CRI) of benzodiazepines or propofol (PPF) is a therapeutic option for cluster seizures (CS) and status epilepticus (SE) in canine patients non-responding to first-line benzodiazepines or non-anesthetics. However, specific indications for optimal duration of CRI are lacking. The aim of this study was to determine the effect of duration of anesthetic CRI on outcome and length of hospital stay in dogs with refractory seizure activity of different etiology. STUDY DESIGN: Open-label non-randomized clinical trial. MATERIALS AND METHODS: Seventy-three client-owned dogs were enrolled. Two groups [experimental (EXP) vs. control (CTRL)] were compared. The EXP group received diazepam (DZP) or PPF CRI for 12 h (±1 h) and the CTRL group received DZP or PPF CRI for 24 h (±1 h) in addition to a standardized emergency treatment protocol identical for both study groups. The historical control group was made up of a population of dogs already reported in a previously published paper by the same authors. Favorable outcome was defined as seizure cessation after CRI, no seizure recurrence, and clinical recovery. Poor outcome was defined as seizure recurrence, death in hospital or no return to acceptable clinical baseline. Univariate statistical analysis was performed. RESULTS: The study sample was 73 dogs: 45 (62%) received DZP CRI and 28 (38%) received PPF CRI. The EXP group was 39 dogs (25 DZP CRI and 14 PPF CRI) and the CTRL group 34 dogs (20 DZP CRI and 14 PPF CRI). We found no statistically significant difference in outcomes between the groups. The median length of stay was 56 h (IQR, 40-78) for the ALL EXP group and 58.5 h (IQR, 48-74.5) for the ALL CTRL group ( = 0.8). CONCLUSION: Even though a shorter DZP or PPF CRI duration was not associated with a worse outcome, the study failed to identify a clear superiority of shorter CRI duration on outcome or length of hospital stay in dogs with refractory seizure activity of different etiology.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37675074/