Peer-reviewed veterinary case report
E-cadherin expression in canine cutaneous histiocytomas.
- Journal:
- The Veterinary record
- Year:
- 2008
- Authors:
- Baines, S J et al.
- Affiliation:
- Department of Clinical Veterinary Medicine · United Kingdom
- Species:
- dog
Abstract
Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen-presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E-cadherin. The expression of E-cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. In all the cases, these cells expressed E-cadherin, whereas the infiltrating lymphocytes did not.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18424847/