Peer-reviewed veterinary case report
How fast Credelio stops lone star ticks on dogs
By Wenger, Martha J et al.·Published in Parasites & vectors·2021·Department of Diagnostic Medicine/Pathobiology, United States·View original on PubMed →
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Original publication title: Early onset of pre-lethal effects of lotilaner (Credelio) on Amblyomma americanum ticks on experimentally infested dogs.
- Species:
- dog
Plain-English summary
A group of healthy dogs was treated with lotilaner (Credelio) to see how quickly it could affect ticks that attached to them. After just a few hours, the ticks on treated dogs showed signs of paralysis and were less able to move compared to those on untreated dogs. By 24 hours, all ticks on the treated dogs were dead, while many ticks on the control dogs remained alive and active. This suggests that lotilaner can effectively disrupt tick attachment and reduce the risk of disease transmission from ticks to dogs.
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Abstract
BACKGROUND: The speed with which acaricides paralyze and kill ticks is relevant to impeding pathogen transmission. The objective of this study was to assess early-onset lotilaner effects on the motility and weights of Amblyomma americanum ticks collected from treated dogs. METHODS: Twelve healthy dogs were randomized between two groups to receive either lotilaner (Credelio) on Day 0 or to be sham treated. On Day 7, 25 male and 25 female A. americanum were placed under bandages, two on each flank of each dog. After 30 or 45 min, all unattached ticks were removed and T = 0 was set. At T = 2, 4, 8 and 24 h post attachment, 5 attached ticks removed from each bandage on each dog were weighed, assessed by blinded observers for righting ability and movement recorded. RESULTS: After the infestation period significantly fewer treated than control dogs had 20 ticks attached (50.0% versus 91.7%, P = 0.0015). At 24 h post attachment, mean weights of ticks from treated dogs (males 1.69 mg; females 2.72) were significantly less than ticks from controls (males 2.66 mg; females 4.67) (P = 0.0002; P < 0.0001). Mean tick weights from the treated group were significantly lower at 24 h than at earlier time points (P < 0.0307; P = 0.0021). At 4 and 8 h, significantly fewer ticks from treated (14.3%, 0.0%, respectively) than from control dogs could right (73.3%, 70.0%) (P < 0.0001; P = 0.0024) (at 24 h, all ticks from treated dogs were dead), and distance moved was significantly less at all time points (P = 0.0413; P, P < 0.0001). Mean and maximum velocity of ticks from treated dogs were significantly lower, relative to controls, at 4 and 8 h (P ≤ 0.0001). Within the treated group, collected ticks had significantly lower mean and maximum velocities at 4 and 8 h compared to 2 h (P < 0.0042; P < 0.0194). CONCLUSION: The observed changes indicate that lotilaner may disrupt tick attachment. In ticks that attached, a progressive impairment of neuromuscular processes began within 2 h. Those irreversible changes could substantially reduce the risk of pathogen transmission from tick to host.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34120646/