Peer-reviewed veterinary case report
Effect of antifungal treatment in a murine model of blastoschizomycosis.
- Journal:
- International journal of antimicrobial agents
- Year:
- 2007
- Authors:
- Serena, Carolina et al.
- Affiliation:
- Unitat de Microbiologia · Spain
- Species:
- rodent
Abstract
Blastoschizomyces capitatus is an emerging pathogenic fungus that can cause deep invasive diseases in neutropenic patients. We developed a model of disseminated blastoschizomycosis in immunosuppressed mice to evaluate the effectiveness of amphotericin B, flucytosine, fluconazole and voriconazole. High-dose fluconazole was the most effective drug at prolonging the survival of mice and at reducing fungal burden in the kidneys, spleen and liver.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17134881/