Peer-reviewed veterinary case report
Evaluation of antifungal therapy in a neutropenic murine model of Neoscytalidium dimidiatum infection.
- Journal:
- International journal of antimicrobial agents
- Year:
- 2010
- Authors:
- Ruíz-Cendoya, Mery et al.
- Affiliation:
- Unitat de Microbiologia · Spain
- Species:
- rodent
Abstract
We evaluated the efficacy of amphotericin B (1.5mg/kg/day), voriconazole (60mg/kg/day) and posaconazole (60mg/kg/day) in a murine model of systemic infection caused by Neoscytalidium dimidiatum. All the treatments were able to prolong survival and to reduce the tissue burden in the spleen and kidneys of infected mice. Neither voriconazole nor posaconazole improved the results achieved with amphotericin B.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20005680/