Peer-reviewed veterinary case report
Desmopressin stops bleeding in dogs with ehrlichiosis-related blood
By Giudice, E et al.·Published in Journal of veterinary pharmacology and therapeutics·2010·Department of Veterinary Public Health, Italy·View original on PubMed →
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Original publication title: Effect of desmopressin on immune-mediated haemorrhagic disorders due to canine monocytic ehrlichiosis: a preliminary study.
- Species:
- dog
Plain-English summary
Three dogs with bleeding problems due to a tick-borne infection called canine monocytic ehrlichiosis were treated with a medication called desmopressin. After receiving the injection, the dogs stopped bleeding within an hour, and their blood tests showed improvements in clotting factors and platelet counts. This suggests that desmopressin can quickly help manage bleeding in dogs affected by this condition, allowing veterinarians to provide further treatment as needed.
People also search for: dog bleeding disorder treatment · canine monocytic ehrlichiosis symptoms · desmopressin for dogs bleeding
Abstract
To evaluate the possible use of desmopressin acetate (DDAVP) in haemorrhagic disorders consequent to canine monocytic ehrlichiosis (CME), three dogs infected by Ehrlichia canis, with a history of thrombocytopenia and recent bleeding, were studied. The dogs were administered desmopressin (1 μg/kg b.w. s.c.) every 24 h on three occasions. Blood samples were collected immediately before, and after 2 and 48 h the first DDAVP administration, to assess haematological, clinical chemistry and clotting time parameters. Spontaneous bleeding stopped within 1 h after the first DDAVP injection. Buccal mucosa bleeding time (BMBT) was shortened from 9.6 to 2.3 min within 2 h after the treatment. A statistically significant increase in platelet PLT count and fibrinogen, and a statistically significant decrease of PT and aPTT were observed after DDAVP administration. The haemorrhagic disorders caused by CME appear to be quickly corrected by DDAVP administration, giving the clinician the time necessary to administer appropriate chemotherapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21108506/