Peer-reviewed veterinary case report
Once daily 0.3% naltrexone eye drops for dogs with dry eye disease
By Chen, Thomas & Powell, Cynthia C·Published in Veterinary ophthalmology·2015·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Effect of once daily topical 0.3% naltrexone on tear parameters and corneal sensitivity in dogs with uncontrolled keratoconjunctivitis sicca: a double-masked randomized placebo-controlled clinical trial.
- Species:
- dog
Plain-English summary
A group of 16 dogs with uncontrolled dry eye (keratoconjunctivitis sicca) received either a daily eye drop containing 0.3% naltrexone or a saline solution for four weeks to see if it would improve their tear production and eye sensitivity. Unfortunately, the study found no significant difference in tear production or eye sensitivity between the two groups after treatment. This means that the naltrexone drops did not help the dogs with their dry eye symptoms.
People also search for: dog dry eye treatment · keratoconjunctivitis sicca in dogs · naltrexone for dogs eyes
Abstract
OBJECTIVE: To determine the effect of once daily topical 0.3% naltrexone (NTX) on tear production, tear film breakup time (TFBUT), and corneal sensitivity in dogs with uncontrolled keratoconjunctivitis sicca (KCS). ANIMALS STUDIED: Sixteen dogs with uncontrolled KCS. PROCEDURES: A randomized placebo-controlled trial was performed in 16 dogs with topical 0.3% NTX once daily or topical saline solution drops once daily. A baseline was obtained at week 0 for tear production (Schirmer tear test 1 and 2-STT1, STT2), TFBUT, and corneal sensitivity. STT1, STT2, and TFBUT were then subsequently measured at weeks 1, 2, and 4 while on NTX or saline drops. Corneal sensitivity measures were repeated at week 4. The drops were subsequently discontinued and all parameters rechecked at week 5. RESULTS: There was no statistically significant difference in tear parameters or corneal sensitivity between the NTX-treated and the saline-treated groups. CONCLUSION: Topical 0.3% NTX given as a once daily dose over 4 weeks did not alter tear production, tear film stability, or corneal sensitivity in dogs with uncontrolled KCS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25675975/