Peer-reviewed veterinary case report
Plasma citrulline levels drop in dogs with parvoviral enteritis
By Dossin, O et al.·Published in Journal of veterinary internal medicine·2011·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: Effect of parvoviral enteritis on plasma citrulline concentration in dogs.
- Species:
- dog
Plain-English summary
A group of 61 dogs with parvoviral enteritis, a serious intestinal infection, had their blood tested for a substance called citrulline, which can indicate gut health. The results showed that dogs with this infection had much lower citrulline levels compared to healthy dogs, but the citrulline levels did not help predict which puppies would survive the illness. Despite the low levels of citrulline, the study found that it did not change significantly over the course of treatment. Unfortunately, the findings suggest that while parvoviral enteritis severely impacts citrulline levels, it doesn't provide useful information about a puppy's chances of recovery.
People also search for: dog parvovirus symptoms · puppy diarrhea treatment · low citrulline levels in dogs
Abstract
BACKGROUND: Plasma citrulline concentration is a reliable marker of global enterocyte mass in humans and is markedly decreased in diffuse small intestinal diseases. However, the relationship between acute intestinal damage and plasma citrulline concentration in dogs has never been documented. HYPOTHESIS: That dogs with parvoviral enteritis have a lower plasma citrulline concentration than healthy dogs and that plasma citrulline concentration is a predictor of death in puppies with parvoviral enteritis. ANIMALS: Sixty-one dogs with spontaneous parvoviral enteritis and 14 healthy age-matched control dogs. METHODS: Observational cohort study. Plasma citrulline concentration was measured by liquid chromatography and tandem mass spectrometry in blood samples collected at admission and each day until death or discharge from the hospital. Parvovirus enteritis was confirmed by electron microscopy on a fecal sample. RESULTS: Median (interquartile range) plasma citrulline concentrations at admission were 2.8 μmol/L (range: 0.3, 49.0; P < .001 versus controls) in survivors (n = 49), 2.1 μmol/L (range: 0.5, 6.4, P < .001 versus controls) in nonsurvivors (n = 12) and 38.6 μmol/L (range: 11.4, 96.1) in controls (n = 14), respectively. There was no significant difference in plasma citrulline concentration between survivors and nonsurvivors within the parvovirus-infected puppies, and plasma citrulline concentration was not significantly associated with outcome in parvoviral enteritis. There were no significant changes in plasma citrulline concentration over the 8-day follow-up period. CONCLUSION AND CLINICAL IMPORTANCE: Parvovirus enteritis is associated with a severe decrease in plasma citrulline concentration that does not appear to have any significant prognostic value.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21281355/