Peer-reviewed veterinary case report
Photodynamic therapy with Chlorin e6 for treating dog tumors
By Rajeev Shrestha et al.·Published in Life·2022·Dongsung Cancer Center, Dongsung Biopharmaceutical, Daegu 41061, Republic of Korea, CH·View original on DOAJ →
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Original publication title: Effect of Photodynamic Therapy with Chlorin e6 on Canine Tumors
- Species:
- dog
Plain-English summary
Five dogs with different types of cancer were treated with a new therapy called photodynamic therapy using a substance called Chlorin e6 (Ce6). After receiving the treatment, two of the dogs showed significant improvement, with their tumors shrinking and their overall health getting better. The therapy involved giving the dogs Ce6 and then shining a specific light on the tumors to help target the cancer cells. This approach not only helped reduce the size of the tumors but also allowed veterinarians to see cancers that were previously hidden. Overall, this treatment shows promise for helping dogs with cancer.
People also search for: dog cancer treatment options · photodynamic therapy for dogs · Chlorin e6 for canine tumors
Abstract
This work aims to prepare pure Chlorin e6 (Ce6) and establish Ce6-mediated photodynamic therapy (Ce6-PDT) as a better therapy option for canine tumors as well as mouse tumor models. Five dogs suffering from various cancers were treated with Ce6-PDT from one to several times. After receiving the Ce6 (2.5 mg/kg) for 3 h, tumors were illuminated superficially or interstitially with 660 nm light. Two dogs underwent Ce6-guided fluorescence imaging by photodynamic diagnosis (PDD). Cell proliferation and apoptosis were detected by the 4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and western blot assay, respectively. Ce6-PDT efficacy was also determined using melanoma and pancreatic cancer mouse models. Two veterinary patients with mammary carcinoma and histiocytic sarcoma had their tumors significantly diminished and showed improved health after receiving Ce6-PDT. Moreover, in the cases of canine tumors, the adjunctive use of Ce6-PDD revealed cancers that were not visible with white light viewing and provided a visual contrast from surrounding tissues. Also, in vivo, Ce6-PDT remarkably reduced melanoma and pancreatic tumors in the mouse model. These findings could pave the way for a better understanding of the underlying processes of Ce6-PDT, making it an effective and safe candidate for use in human and veterinary applications to abolish various cancers.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/life12122102