Peer-reviewed veterinary case report
How anesthesia and seizure drugs affect dog seizure tests
By Parmentier, Thomas et al.·Published in Journal of veterinary internal medicine·2020·Department of Biomedical Sciences, Canada·View original on PubMed →
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Original publication title: Effect of prior general anesthesia or sedation and antiseizure drugs on the diagnostic utility of wireless video electroencephalography in dogs.
- Species:
- dog
Plain-English summary
A group of 108 dogs experiencing unusual episodes underwent a special test called ambulatory wireless video electroencephalography (AEEG) to help determine if they were having seizures. The study found that the test was able to provide useful results in about 60% of the dogs, with slightly better outcomes in those that weren't sedated or given anesthesia beforehand. Additionally, the use of antiseizure medications didn't seem to affect the test's ability to identify problems. Overall, the findings suggest that sedation or medication prior to the test won't hinder its effectiveness, and a recording period of at least four hours is recommended for the best results.
People also search for: dog seizure diagnosis · AEEG for dogs · effects of sedation on dog seizures · dog epilepsy treatment options
Abstract
BACKGROUND: Ambulatory wireless video electroencephalography (AEEG) is the method of choice to discriminate epileptic seizures from other nonepileptic episodes. However, the influence of prior general anesthesia (GA), sedation, or antiseizure drug (ASD) on the diagnostic ability of AEEG is unknown. HYPOTHESIS/OBJECTIVES: The use of sedation/GA or ASD treatment before AEEG recording may affect the diagnostic ability of AEEG and the time to first abnormality on AEEG. ANIMALS: A total of 108 client-owned dogs undergoing ambulatory AEEG for paroxysmal episodes. METHODS: Retrospective cohort study. Proportions of diagnostic AEEG and time to first abnormality were compared between dogs that received sedation/GA or neither for instrumentation as well as dogs receiving at least 1 ASD and untreated dogs. RESULTS: Ambulatory EEG was diagnostic in 60.2% of all dogs including 49% of the sedation/GA dogs and 68% of dogs that received neither (odds ratio [OR], 2.25; 95% confidence interval [CI], 1.02-5.00; P = .05). The AEEG was diagnostic in 51% of dogs receiving at least 1 ASD and 66% of untreated dogs (OR, 1.95; 95% CI, 0.9-4.3; P = .11). No difference was found in time to first abnormality between sedation/GA or neither or ASD-treated or untreated dogs (P = .1 and P = .3 respectively). Ninety-five percent of dogs had at least 1 abnormality within 277 minutes. CONCLUSION AND CLINICAL IMPORTANCE: Sedation/GA and concurrent ASD administration were not identified as confounding factors for decreasing AEEG diagnostic capability nor did they delay the time to first abnormality. A 4-hour minimal recording period is recommended.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33463773/