Peer-reviewed veterinary case report
Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model.
- Journal:
- American journal of orthopedics (Belle Mead, N.J.)
- Year:
- 2008
- Authors:
- Herbenick, Michael A et al.
- Affiliation:
- Department of Orthopaedic Surgery · United States
- Species:
- rodent
Abstract
Since the advent of cyclooxygenase 2 (COX-2) inhibitors, little research has been done on the effects of these medications on fracture healing. In the study reported here, we sought to determine whether a COX-2 inhibitor, celecoxib, affects strength and amount of healing callus formed after a fracture. Forty-eight male Sprague-Dawley rats were evaluated for impairment of fracture healing with celecoxib use. Compared with controls, celecoxib-treated rats had a significant decrease in force required for refracture (P = .0199). We do not recommend routine use of celecoxib in postfracture pain control, particularly when fracture union is tenuous.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18795192/