Peer-reviewed veterinary case report
Dog vaginal fibroma with bleeding and tenesmus
By Rollón, E et al.·Published in The Journal of small animal practice·2008·Small Animal Clinic Canymar, Spain·View original on PubMed →
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Original publication title: Effects of aglepristone, a progesterone receptor antagonist, in a dog with a vaginal fibroma.
- Species:
- dog
Plain-English summary
A 12-year-old female crossbreed dog was brought in for vulval bleeding, a bulging area near her rear, and difficulty passing stool. The vet found a large, firm mass in her perineum that was not painful. After giving her a medication called aglepristone over several weeks, the symptoms improved, and the mass shrank by half before surgery. This treatment helped reduce the size of the vaginal tumor, making it easier for the dog to recover.
People also search for: dog vaginal bleeding treatment · dog perineal mass · aglepristone for dog tumors
Abstract
A 12-year-old, entire, nulliparous crossbreed female dog was presented with a history of vulval bleeding, bulging of the perineum and faecal tenesmus. A firm, non-painful perineal mass, measuring 9.11x5.4 cm, with erythema was detected. Abdominal radiography showed compression and elevation of the rectal ampulla. A dose of 10 mg/kg aglepristone was administered subcutaneously on days 1, 2, 8, 15, 28 and 35. An incision biopsy was taken on day 15 and immunohistochemical analysis showed that the majority of neoplastic cells expressed progesterone receptors. Both the cutaneous erythema and the faecal tenesmus had resolved by day 28. A 50 per cent reduction in size was observed by day 60 (surgical excision). This study shows that benign tumours of the vagina of the dog that contain progesterone receptors can be reduced in size in a palliative or neoadjuvant setting using the progesterone receptor antagonist aglepristone.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17784929/