Peer-reviewed veterinary case report
Calcifediol supplements and bone health in dogs with kidney disease
By Parker, Valerie J et al.·Published in Journal of veterinary internal medicine·2020·The Ohio State University Veterinary Medical Center, United States·View original on PubMed →
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Original publication title: Effects of calcifediol supplementation on markers of chronic kidney disease-mineral and bone disorder in dogs with chronic kidney disease.
- Species:
- dog
Plain-English summary
Ten dogs with chronic kidney disease (CKD) received a vitamin D supplement called calcifediol for 84 days to see if it would help with their kidney-related bone and mineral issues. By the end of the study, all dogs showed significant increases in their vitamin D levels, which is a positive sign. However, there were no major changes in other important markers like calcium and phosphorus levels. The dogs tolerated the treatment well, but it's still unclear how this supplement might affect their long-term kidney health and quality of life.
People also search for: dog chronic kidney disease treatment · calcifediol for dogs · vitamin D for dog kidney disease
Abstract
BACKGROUND: Chronic kidney disease-mineral and bone disorder (CKD-MBD) in dogs is associated with hypovitaminosis D, increased parathyroid hormone (PTH), and increased fibroblast growth factor-23 (FGF-23) concentrations. Best practice for vitamin D metabolite supplementation in CKD-MBD remains unknown. OBJECTIVE: To provide an extended-release calcifediol supplement to dogs with CKD and to measure its effects on variables indicative of CKD-MBD. ANIMALS: Ten dogs with International Renal Interest Society stages 2 and 3 CKD. METHODS: In a prospective study, dogs received a calcifediol supplement for 84 days. Serum 25-hydroxyvitamin D (25[OH]D), 1,25-dihydroxyvitamin D (1,25[OH]D), 24,25-dihydroxyvitamin D (24,25[OH]D), creatinine, calcium, phosphorus, PTH, plasma FGF-23 concentrations, and urine profiles were measured monthly during supplementation. Urine calcium to creatinine (UCa/Cr) ratios and fractional excretion of calcium, phosphorus, and sodium were determined. RESULTS: All serum vitamin D metabolite concentrations increased significantly by day 84 (P < .001): [25(OH)D (median 249.9 ng/mL; range, 149.7-469.9 ng/mL) compared to baseline (median 50.2 ng/mL; range, 31.3-66.0 ng/mL); 1,25(OH)D (median 66.1 pg/mL; range, 56.9-88.1 pg/mL) compared to baseline (median 37.3 pg/mL; range, 29.3-56.7 pg/mL); 24,25(OH)D (median 81.4 ng/mL; range, 22.1-151.7 ng/mL) compared to baseline (median 15.4 ng/mL; range, 6.9-40.6 ng/mL)]. There were no significant differences in calcium, phosphorus, PTH concentrations, UCa/Cr or fractional excretion of calcium. No dog developed ionized hypercalcemia. Plasma FGF-23 concentrations increased by day 84 (median 1219 pg/mL; range, 229-8824 pg/mL) compared to baseline (median 798 pg/mL; range, 103-4.145 pg/mL) (P < .01). CONCLUSIONS AND CLINICAL IMPORTANCE: Calcifediol supplementation for 84 days was well-tolerated in dogs with IRIS stages 2 and 3 CKD. It remains to be determined how long-term supplementation would affect CKD progression and QOL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33128421/