Peer-reviewed veterinary case report
Canine flu infection and DA2PP vaccine effects on dog platelets
By Williams, Maggie et al.·Published in Veterinary clinical pathology·2024·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Effects of canine influenza infection and DA2PP vaccination on the development of platelet-associated immunoglobulins and platelet counts in dogs.
- Species:
- dog
Plain-English summary
A group of Beagles developed low platelet counts after being infected with the H3N2 strain of canine influenza, which caused some dogs to show signs of immune response. One dog became notably thrombocytopenic (low platelet count) and tested positive for platelet-associated immunoglobulins (PAIg), indicating an immune reaction. In contrast, dogs vaccinated for distemper, adenovirus-2, parainfluenza, and parvovirus (DA2PP) did not experience significant drops in platelet counts or develop PAIg. Most dogs returned to normal after the influenza infection, and the vaccination appeared safe without causing serious side effects.
People also search for: dog influenza symptoms · Beagle low platelet count treatment · DA2PP vaccination side effects
Abstract
BACKGROUND: Immune thrombocytopenia (ITP) is commonly associated with platelet-associated immunoglobulins (PAIg). Demonstration of PAIg can help determine etiologies for thrombocytopenia. In humans, ITP and thrombocytopenia have been associated with various vaccinations and influenza infections, respectively. OBJECTIVES: We aimed to evaluate platelet counts and PAIg in research dogs with H3N2 and in research and client-owned dogs routinely vaccinated for distemper, adenovirus-2, parainfluenza, and parvovirus (DA2PP). The hypotheses were that H3N2 infection but not DA2PP vaccination would decrease platelet counts, and neither would result in the detection of PAIg. METHODS: Three pilot studies. Platelet counts and PAIg, measured by direct flow cytometry as %IgG, were evaluated in eight research Beagles following experimental infection with H3N2 (experiment 1), nine research Beagles vaccinated for DA2PP (experiment 2), and thirty client-owned dogs vaccinated for DA2PP (experiment 3). All animals were considered healthy at the start of the experiments. RESULTS: Transient, self-resolving decreases in platelet counts and increases in %IgG occurred following H3N2 infection, and one dog became thrombocytopenic and positive for PAIg. Following DA2PP vaccination, %IgG increased in research and client-owned dogs, but only one dog was considered positive for PAIg with a concurrent increase in platelet count. Mean PAIg increased from baseline in client-owned dogs following vaccination. CONCLUSIONS: Transient PAIg and thrombocytopenia can occur following H3N2 infection, while routine vaccination for DA2PP in this group of dogs was not associated with the development of thrombocytopenia or clinically relevant formation of PAIg.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38433107/