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Peer-reviewed veterinary case report

Effects of modified amphotericin in experimental systemic candidiasis.

Journal:
Bulletin of experimental biology and medicine
Year:
2007
Authors:
Shkurupy, V A et al.
Affiliation:
Research Center of Clinical and Experimental Medicine
Species:
rodent

Abstract

Lysosomotropic composition of dialdehyde dextran and amphotericin B had a greater therapeutic effect in mice with systemic candidiasis compared to free amphotericin B. This composition normalized glucocorticoid function of the adrenal glands and decreased the severity of liver destruction at late terms of granulomatous inflammation.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/18214282/