Peer-reviewed veterinary case report
Effects of nafamostat mesilate on 5-hydroxytryptamine release from isolated ileal tissues induced by anti-cancer drugs in rats.
- Journal:
- Biomedical research (Tokyo, Japan)
- Year:
- 2020
- Authors:
- Kikuchi, Kaoru et al.
- Affiliation:
- Department of Pharmacological Sciences · Japan
- Species:
- rodent
Abstract
Administration of cisplatin and methotrexate significantly increased 5-hydroxytryptamine (5-HT) release from intestinal tissues isolated at 72 h after administration in rats. Daily administration with nafamostat mesilate, a potent serine protease inhibitor, significantly inhibited the release of 5-HT induced by methotrexate, but not by cisplatin, in a dose-dependent manner. When applied to isolated ileal tissues in vitro, nafamostat mesilate also significantly inhibited the release of 5-HT induced by methotrexate, but not by cisplatin, in a concentration-dependent manner. These results suggest that serine proteases are involved in the mechanism of the methotrexate-induced release of 5-HT from the rat small intestine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33071261/