Effects of probiotic VSL#3 on glomerular filtration rate in dogs affected by chronic kidney disease: A pilot study.

Abstract

The aim of this study was to evaluate the effects of probiotic VSL#3 on glomerular filtration rate (GFR) in dogs affected by chronic kidney disease (CKD). The treatment group (= 30) received prescription renal diet and probiotic VSL#3 (112 to 225 × 10lyophilized bacteria per 10 kg body weight, PO, q24h for 2 months); the control group (= 30) received prescription renal diet and standard therapy. All dogs underwent GFR measurement at the beginning of the study (T0) and were re-evaluated by GFR measurement after 2 months (T1). The GFR was significantly higher (= 0.0001) in the treatment group compared to the control group at T1. In the treatment group, the GFR was significantly higher (= 0.0008) at T1 compared to T0. In the control group, the GFR was significantly lower (= 0.001) at T1 compared to T0. VSL#3 supplementation seemed to be efficient in reducing deterioration of GFR over time in dogs affected by CKD.