Peer-reviewed veterinary case report
Toceranib phosphate treatment for drug resistant lymphoma in dogs
By Yamazaki, Hiroki et al.·Published in The Journal of veterinary medical science·2017·Veterinary Teaching Hospital, Japan·View original on PubMed →
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Original publication title: Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma in dogs.
- Species:
- dog
Plain-English summary
A dog with multidrug resistant lymphoma was treated with toceranib phosphate (Palladia) to see if it could help. The treatment was well tolerated, meaning the dog didn't have serious side effects, and two out of five dogs showed some improvement in their condition. This suggests that toceranib phosphate might be a useful option for dogs dealing with this tough type of cancer.
People also search for: dog lymphoma treatment · toceranib phosphate for dogs · multidrug resistant lymphoma in dogs
Abstract
We examined whether multidrug resistant (MDR) canine lymphoma increases gene expression for platelet-derived growth factor receptor α (PDGFRα), vascular endothelial growth factor receptor 2 (VEGFR2), and c-KIT, and whether toceranib phosphate (TOC) has potential as a treatment for MDR canine lymphoma. The clinical data showed that PDGFRα expression was higher in canine subjects with MDR T-cell lymphoma than in those with untreated T-cell lymphoma, and that c-KIT expression was greater in subjects with T-cell lymphoma than in those with B-cell lymphoma. TOC monotherapy was well tolerated without serious adverse effects, and two of the five subjects that received TOC exhibited partial responses. The data presented here could contribute to the assessment of TOC-based therapy for dogs with MDR or T-cell lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28592719/