Peer-reviewed veterinary case report
Effects of YM529, a novel minodronic acid, on adjuvant arthritis in rats.
- Journal:
- Clinical and experimental rheumatology
- Year:
- 2004
- Authors:
- Masuda-Aiba, S et al.
- Affiliation:
- Department of Orthopaedic Surgery
- Species:
- rodent
Abstract
OBJECTIVE: The effects of a new third-generation bisphosphonate, YM529, on both the development and treatment of adjuvant arthritis were investigated in rats. METHODS: Five-week-old Lewis rats with adjuvant arthritis were prophylactically and therapeutically treated with 0.001, 0.01 and 0.05 mg/kg/day of YM529 and the arthritis scores were measured. Soft X-ray and histological finding were compared to those of the control group. Body weights were also measured. RESULTS: YM529 suppressed the severity of adjuvant arthritis in a dose-dependent manner when used as either a prophylactic or therapeutic drug. Administration of the drug had little effect on body weight. CONCLUSION: YM529 may act on arthritic joints locally to prevent inflammation. However, further experiments are necessary to elucidate the underlying mechanisms.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15005007/