Peer-reviewed veterinary case report
Effects on bone union and prevention of tendon adhesion by new porous anti-adhesive poly L-lactide-co-ε-caprolactone membrane in a rabbit model.
- Journal:
- Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
- Year:
- 2013
- Authors:
- Sato, Takuya et al.
- Affiliation:
- Department of Orthopaedic Surgery · Japan
- Species:
- rabbit
Abstract
To prevent adhesion between the tendon and the plate in hand surgery, a porous poly L-lactide-co-ε-caprolactone (P(LA/CL)) membrane was developed as a biologically absorbable anti-adhesion material. Our study aims to confirm the efficacy of this new P(LA/CL) membrane and its influences on the osteotomy site by performing a fundamental experiment assessing the possibility of clinical application. We prepared a rabbit model of tendon-plate adhesion, and evaluated the efficacy of the P(LA/CL) membrane to pullout tendon strength, to be scored in terms of macroscopic, pathological results. Another rabbit model of osteotomy was prepared to confirm the P(LA/CL) membrane influences on bone union by radiological, mechanical and pathological evaluation. The result showed to be significantly lower adhesion in the P(LA/CL) membrane group than in the control group. Also there were no differences between the P(LA/CL) membrane group and control group in the results for bone union.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23413842/