Peer-reviewed veterinary case report
Paclitaxel cancer treatment in dogs caused allergic reactions
By Poirier, V J et al.Ā·Published in Journal of veterinary internal medicineĀ·2004Ā·Department of Medical Sciences, United StatesĀ·View original on PubMed ā
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Original publication title: Efficacy and toxicity of paclitaxel (Taxol) for the treatment of canine malignant tumors.
- Species:
- dog
Plain-English summary
Twenty-five dogs with confirmed malignant tumors were treated with paclitaxel (Taxol) to see if it could help shrink their tumors. Unfortunately, many dogs had allergic reactions, and some experienced severe side effects like low white blood cell counts, which led to hospitalizations and even a few deaths. Only five dogs showed some improvement in their tumors, but this lasted only about seven weeks. Due to the high level of toxicity at the initial dose, a lower dose will be tested in future treatments.
People also search for: dog cancer treatment paclitaxel Ā· side effects of Taxol in dogs Ā· malignant tumors in dogs treatment
Abstract
Paclitaxel (Taxol) was administered to 25 dogs with histologically confirmed malignant tumors at a dosage of 165 mg/m2 i.v. over 3-6 hours every 3 weeks. Dogs received premedication with antihistimines and corticosteroids to reduce hypersensitivity reactions. However, 64% of the dogs still experienced allergic reactions. Six dogs (24%) had grade 3 or 4 neutropenia, 6 dogs (24%) required hospitalization and 3 dogs (12%) died of sepsis. Five dogs (20%) had a partial response (osteosarcoma [2 dogs] mammary carcinoma [2 dogs] and malignant histiocytosis [1 dog]) for a median duration of 53 days. The overall toxicity was unacceptable at the 165 mg/m2 dose. Therefore, subsequent evaluations of paclitaxel in tumor-bearing dogs should a starting dose of 132 mg/m2 i.v. every 3 weeks.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15058774/