Peer-reviewed veterinary case report
Gold nanorod laser treatment for mammary tumors in dogs and cats
By Abdoon, Ahmed S et al.·Published in Nanomedicine : nanotechnology, biology, and medicine·2016·Animal Reproduction Department·View original on PubMed →
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Original publication title: Efficacy and toxicity of plasmonic photothermal therapy (PPTT) using gold nanorods (GNRs) against mammary tumors in dogs and cats.
Plain-English summary
A group of 10 dogs and 6 cats with mammary tumors received a new treatment called plasmonic photothermal therapy, which involved injecting gold nanorods and then using a laser to target the tumors. After treatment, 62.5% of the pets showed complete remission, while 25% had partial remission, and only 12.5% did not respond. The treatment was found to be safe, with no harmful effects on blood, liver, or kidney functions. Overall, the pets lived an average of about 315 days after treatment, showing promising results for this new cancer therapy.
People also search for: dog mammary tumor treatment · cat cancer therapy · gold nanorods for pets · photothermal therapy for dogs · mammary tumor remission in cats
Abstract
Plasmonic photothermal therapy (PPTT) was introduced as a promising treatment of cancer. This work was conducted to evaluate the cytotoxic effect of intratumoral (IT) injection of 75μg gold nanorods (GNRs)/kg of body weight followed by direct exposure to 2 w/cmnear infra-red laser light for 10min on ablation of mammary tumor in 10 dogs and 6 cats. Complete blood count (CBC), liver and kidney function were checked before the start of treatment and one month after injection of GNRs. Results showed that 62.5% (10/16), 25% (4/16) and 12.5% (2/16) of treated animals showed complete remission, partial remission and no response, respectively. Tumor was relapsed in 4 cases of initially responding animals (25%). Overall survival rate was extended to 315.5±20.5days. GNRs have no toxic effect on blood profile, liver or kidney functions. In conclusion, GNRs can be safely used for treatment of mammary tumors in dogs and cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27453263/