Peer-reviewed veterinary case report
Once-daily supplement helps manage chronic kidney disease in dogs
By Francesca Perondi et al.·Published in Animals·2025·Department of Veterinary Science, University of Pisa, San Piero a Grado, 56122 Pisa, Italy, CH·View original on DOAJ →
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Original publication title: Efficacy of a Once-Daily Supplement in Managing Canine Chronic Kidney Disease
- Species:
- dog
Plain-English summary
A group of 30 dogs with chronic kidney disease (CKD) were given either a special renal supplement or a placebo along with their regular diet for 90 days. The dogs receiving the supplement showed significant improvements, including lower levels of protein in their urine and reduced blood urea and phosphorus levels. Their kidney function markers also stabilized, and they experienced less inflammation. This supplement made it easier for owners to manage their dogs' diets, especially for those who were picky eaters or on multiple medications. Overall, the supplement proved to be a helpful addition to the treatment of CKD in dogs.
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Abstract
Background: Chronic kidney disease (CKD) in companion animals leads to progressive renal deterioration and metabolic complications such as hyperphosphatemia and metabolic acidosis, particularly in advanced stages. Methods: This 90-day, double-blind, randomized controlled study evaluated the effects of a renal supplement (Renal Combi, Candioli srl, Beinasco, Turin, Italy) in 30 dogs diagnosed with CKD. Dogs were randomly assigned to a treatment group (TRT, <i>n</i> = 15), receiving a commercial renal diet plus the supplement (once daily), or a control group (CTR, <i>n</i> = 15), receiving the same diet and a placebo. Results: Results showed that supplementation effectively reduced proteinuria, blood urea, and phosphorus levels, stabilized creatinine and SDMA, and maintained blood pressure. It also improved markers of systemic inflammation and oxidative stress. Conclusions: The once-daily dosage simplified administration and was especially beneficial for hyporexic dogs or those on multiple medications. This study supports the use of the tested supplement as an effective adjunctive therapy for managing CKD in dogs, offering metabolic, renal, and nutritional benefits while enhancing compliance through convenient dosing.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3390/ani15192884