Peer-reviewed veterinary case report
Efficacy of a Once-Daily Supplement in Managing Canine Chronic Kidney Disease
- Journal:
- Animals
- Year:
- 2025
- Authors:
- Francesca Perondi et al.
- Affiliation:
- Department of Veterinary Science, University of Pisa, San Piero a Grado, 56122 Pisa, Italy · CH
- Species:
- dog
Plain-English summary
Chronic kidney disease (CKD) is a serious condition in dogs that can lead to worsening kidney function and other health issues. In a study lasting 90 days, researchers looked at the effects of a daily supplement called Renal Combi in 30 dogs with CKD. Half of the dogs received the supplement along with a special diet, while the other half got a placebo with the same diet. The results showed that the supplement helped lower protein levels in the urine, reduced blood urea and phosphorus levels, and stabilized other important health markers. Overall, the supplement was found to be an effective addition to the treatment of CKD in dogs, making it easier for owners to manage their pets' health.
Abstract
Background: Chronic kidney disease (CKD) in companion animals leads to progressive renal deterioration and metabolic complications such as hyperphosphatemia and metabolic acidosis, particularly in advanced stages. Methods: This 90-day, double-blind, randomized controlled study evaluated the effects of a renal supplement (Renal Combi, Candioli srl, Beinasco, Turin, Italy) in 30 dogs diagnosed with CKD. Dogs were randomly assigned to a treatment group (TRT, <i>n</i> = 15), receiving a commercial renal diet plus the supplement (once daily), or a control group (CTR, <i>n</i> = 15), receiving the same diet and a placebo. Results: Results showed that supplementation effectively reduced proteinuria, blood urea, and phosphorus levels, stabilized creatinine and SDMA, and maintained blood pressure. It also improved markers of systemic inflammation and oxidative stress. Conclusions: The once-daily dosage simplified administration and was especially beneficial for hyporexic dogs or those on multiple medications. This study supports the use of the tested supplement as an effective adjunctive therapy for managing CKD in dogs, offering metabolic, renal, and nutritional benefits while enhancing compliance through convenient dosing.
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Search related cases →Original publication: https://doi.org/10.3390/ani15192884