Peer-reviewed veterinary case report
Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation.
- Journal:
- Behavioural brain research
- Year:
- 2008
- Authors:
- Snigdha, Shikha & Neill, Joanna C
- Affiliation:
- The School of Pharmacy · United Kingdom
- Species:
- rodent
Abstract
Sub-chronic phencyclidine (PCP) treatment mimics certain aspects of schizophrenia symptomology in rats. However, there is a marked lack of attempts to model negative symptomology such as social behaviour deficits in female rats. This study was conducted to assess whether sub-chronic PCP treatment produces social interaction deficits in female rats and to ascertain if these deficits can be reversed by either typical (haloperidol) or atypical (clozapine and ziprasidone) antipsychotics.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18037171/