Peer-reviewed veterinary case report
Antivascular photodynamic therapy helps dogs with oral and nasal
By Osaki, Tomohiro et al.·Published in The Journal of veterinary medical science·2009·Department of Veterinary Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Efficacy of antivascular photodynamic therapy using benzoporphyrin derivative monoacid ring A (BPD-MA) in 14 dogs with oral and nasal tumors.
- Species:
- dog
Plain-English summary
Fourteen dogs with oral and nasal tumors were treated with a new therapy called antivascular photodynamic therapy (PDT) using a special drug. After receiving the drug through an IV, the tumors were targeted with laser light. The results showed that 71% of dogs with oral tumors and 57% of those with nasal tumors survived for at least a year after treatment. Imaging tests indicated that the tumors responded well to the therapy, showing reduced blood flow after treatment. This method appears to be a promising option for dogs whose tumors are difficult to treat with standard therapies.
People also search for: dog oral tumor treatment · nasal tumor in dogs survival rate · photodynamic therapy for dogs
Abstract
Antivascular photodynamic therapy (PDT) suppresses tumor growth and prolonged the survival in solid tumor-bearing mice. The purpose of this study was to assess the efficacy of antivascular PDT using BPD-MA for treatment of oral and nasal tumors in 14 dogs. At 15 min after initiating intravenous infusion of 0.5 mg/kg benzoporphyrin derivative monoacid ring A, tumors were irradiated with laser light at 690 nm emitted by a diode laser. The 1-year survival rate of 7 dogs with oral tumors was 71%. The 1-year survival rate of 7 dogs with nasal tumors was 57%. Imaging of each tumor was performed by using angiographic computed tomography before and after each antivascular PDT. Contrast-enhanced tumors were observed before antivascular PDT, but these tumors were not enhanced with contrast medium following antivascular PDT. Antivascular PDT is suggested to be a promising method for dogs with oral and nasal tumors that cannot be effectively treated with current antitumor therapies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19262021/