Peer-reviewed veterinary case report
Cyclosporine helps chronic mouth inflammation in cats after tooth
By Lommer, Milinda J·Published in Journal of veterinary dentistry·2013·Aggie Animal Dental Center, United States·View original on PubMed →
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Original publication title: Efficacy of cyclosporine for chronic, refractory stomatitis in cats: A randomized, placebo-controlled, double-blinded clinical study.
- Species:
- cat
Plain-English summary
A group of 16 cats with chronic stomatitis (inflammation of the mouth) that had already undergone tooth extractions were given either cyclosporine or a placebo for six weeks. The cats receiving cyclosporine showed a significant improvement in their symptoms, with 77.8% of them experiencing over 40% improvement in their condition, compared to just 14.3% in the placebo group. The study found that higher levels of cyclosporine in the blood were linked to better results, suggesting that this medication can effectively reduce oral inflammation in cats suffering from this painful condition.
People also search for: cat stomatitis treatment · cyclosporine for cats · chronic mouth inflammation in cats
Abstract
Sixteen cats with chronic stomatitis, that had previously undergone premolar-molar or full-mouth extractions, were randomly assigned a group to receive 2.5 mg/kg cyclosporine or placebo orally twice daily Neither the clinician nor the clients were aware of the group assignments. Cats were evaluated prior to treatment and every 2 weeks for 6 weeks using a 30 point Stomatitis Disease Activity Index (SDAI) score. Mean improvement in SDAI scores among cats in the treatment group after 6 weeks was 52.7 %. This was significantty diffrent fom the mean improvement (12.2 %) of cats in the placebo group. During the 6 week study period, 7 of the 9 cats in the treatment group (77.8 %) showed a > 40 % improvement in SDAI score, while 1 of 7 cats in placebo group (14.3 %) showed a > 40 % improvement in SDAI score. This difference was statistically significant. Individual variability in the absorption of orally-administered cyclosporine was high. Trough whole-blood cyclosporine levels ranged firm 32.1 ng/ml to 1,576.2 ng/ml. At the end of the 6 week observation period, there was a statistically significant diference among cats with trough whole-blood cyclosporine levels >300 ng/ml (72.3 % improvement) compared with cats with cyclosporine levels < 300 ng/ml (28.2 % improvement). Whole-blood cyclosporine levels > 300 ng/ml were associated with significant improvement in oral inflammation in cats with chronic stomatitis that had previously undergone premolar-molar or fuill-mouth extraction.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23757820/