Peer-reviewed veterinary case report
Treatment of dogs with leishmaniosis using metronidazole
By Pennisi, M G et al.·Published in The Veterinary record·2005·Dipartimento di Scienze Mediche Veterinarie, Italy·View original on PubMed →
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Original publication title: Efficacy of the treatment of dogs with leishmaniosis with a combination of metronidazole and spiramycin.
- Species:
- dog
Plain-English summary
A group of 27 dogs with leishmaniosis (a disease caused by a parasite) were treated with either a combination of metronidazole and spiramycin or a standard treatment of meglumine antimonate and allopurinol. While both treatments showed some clinical improvement, neither completely cured the infection. The dogs receiving the standard treatment started to feel better after about 30 days, while those on the new combination treatment took around 45 days to show any signs of improvement. Unfortunately, none of the dogs were fully cured of the parasite.
People also search for: dog leishmaniosis treatment · metronidazole for dogs · spiramycin side effects in dogs
Abstract
Twenty-seven dogs infected naturally with Leishmania infantum were used in a randomised controlled trial to compare the clinical and parasitological efficacy of an oral treatment with a combination of metronidazole and spiramycin (13 dogs) with the efficacy of conventional treatment with meglumine antimonate and allopurinol (14 dogs) as controls. In the test group one dog had to be withdrawn from the treatment because it developed pemphigus foliaceus; 10 of the dogs were clinically responsive but none was cured parasitologically. In the control group four dogs were withdrawn from the treatment because of side effects; eight of the dogs were clinically responsive but none was cured parasitologically. The control group showed signs of improvement after an average of 30 days, whereas the test group did not show signs of improvement until after an average of 45 days.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15789648/