Peer-reviewed veterinary case report
Tinidazole treatment clears Tritrichomonas foetus infection in cats
By Gookin, Jody L et al.·Published in American journal of veterinary research·2007·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Efficacy of tinidazole for treatment of cats experimentally infected with Tritrichomonas foetus.
- Species:
- cat
Plain-English summary
Eight kittens were infected with a parasite called Tritrichomonas foetus to see if a medication called tinidazole could help treat the infection. The kittens received tinidazole for 14 days, and while it reduced the parasite in some of them, it didn't completely eliminate it in most cases. When the researchers later induced diarrhea to test for the parasite again, the kittens that had received tinidazole showed less shedding of the parasite. However, since the medication didn't fully clear the infection in many kittens, it may not be a reliable treatment option for this condition in cats.
People also search for: cat diarrhea treatment · kitten parasite infection · tinidazole for cats · Tritrichomonas foetus in cats · cat medication for parasites
Abstract
OBJECTIVE: To determine the efficacy of tinidazole for treatment of cats with experimentally induced Tritrichomonas foetus infection. ANIMALS: 8 specific-pathogen-free kittens. PROCEDURES: Tinidazole was tested for activity against a feline isolate of T foetus in vitro. Kittens were infected orogastrically with the same isolate and treated or not with tinidazole (30 mg/kg, PO, q 24 h for 14 days). Amoxicillin was administered 28 weeks after completion of tinidazole administration to induce diarrhea. Feces were repeatedly tested for T foetus by use of PCR assay and microbial culture for 33 weeks. RESULTS: Tinidazole killed T foetus at concentrations >or= 10 microg/mL in vitro. In experimentally induced infection, tinidazole administered at 30 mg/kg decreased T foetus below the limit of molecular detection in 2 of 4 cats. Recrudescent shedding of T foetus, as elicited by amoxicillin-induced diarrhea, was diminished in cats that received prior treatment with tinidazole. CONCLUSIONS AND CLINICAL RELEVANCE: Although tinidazole decreased the detection of T foetus and treated cats were resistant to later efforts to incite the infection, inability of tinidazole to eradicate infection in many cats poses a serious impediment to the drug's effectiveness in practice.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17916015/