Peer-reviewed veterinary case report
Electrochemotherapy in Veterinary Oncology: State-of-the-Art and Perspectives.
- Journal:
- The Veterinary clinics of North America. Small animal practice
- Year:
- 2019
- Authors:
- Spugnini, Enrico Pierluigi & Baldi, Alfonso
- Affiliation:
- Biopulse srl · Italy
Plain-English summary
Electrochemotherapy is a treatment for pets with tumors that helps cancer-fighting drugs work better. It uses special electric pulses to help drugs like bleomycin and cisplatin enter the cancer cells much more effectively—up to 700 times better for bleomycin and 4 to 8 times for cisplatin. This method is gaining popularity in veterinary medicine because it can be used alongside surgery or as a primary treatment, whether to help manage the disease or to try to cure it. Overall, it offers a promising option for treating cancer in pets with fewer side effects.
Abstract
Tumor microenvironment represents a key obstacle for the effectiveness of anticancer drugs. Electrochemotherapy involves the systemic or local delivery of lipophobic drugs such as bleomycin and cisplatin, with the application of permeabilizing electric pulses having appropriate amplitude and waveforms. This greatly enhances the uptake of these drugs by an estimated factor of 700-fold for bleomycin and 4 to 8 times for cisplatin. Because of its efficacy and limited morbidity, this therapeutic option is becoming more and more available in veterinary oncology either as an adjuvant to surgery or as first line of treatment with palliative or curative purposes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31176458/