Peer-reviewed veterinary case report
Urine protein changes in dogs with chronic kidney disease stages
By L.T. Patitucci et al.·Published in Arquivo Brasileiro de Medicina Veterinária e Zootecnia·2020·View original on DOAJ →
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Original publication title: Electrophoretic analysis (sds-page) of canine urinary proteins according to the stage of chronic kidney disease
- Species:
- dog
Plain-English summary
A group of 28 dogs with chronic kidney disease (CKD) were studied to understand how their urinary proteins changed as the disease progressed. The researchers found that dogs with CKD were losing more high-molecular-weight proteins, which indicates damage to the kidneys, especially in the later stages of the disease. This suggests that as CKD worsens, the kidneys struggle more with filtering out proteins. The study supports using a specific test (SDS-PAGE) to evaluate kidney health in dogs with CKD.
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Abstract
ABSTRACT Glomerular proteinuria is characterized by the loss of high-molecular-weight proteins (HMWPs), while tubulointerstitial proteinuria is characterized by the loss of low-molecular-weight proteins (LMWPs). The objective was to assess the molecular weight of urinary proteins (MWUP) in dogs with naturally acquired CKD and determine the proportion of HMWPs and LMWPs according to CKD stage. Twenty-eight dogs with CKD were recruited and divided into 4 groups based on serum creatinine (Cr) levels (group1: Cr<1,4, n=8; group2: 1,4<Cr<2,0, n=6; group3: 2,1<Cr<5, n=9; group4: Cr>5,0, n=5). The control group consisted of 5 healthy dogs. The MWUP was determined by SDS-PAGE. The urinary protein-to-creatinine ratio (UP/C) was used to quantitatively assess proteinuria. The electrophoresis pattern revealed a proportionally greater loss of HMWPthan of LMWP in all groups with CKD and an increased loss of LMWP in group 4 (P<0.05). These results suggest a predominance of glomerular injuries throughout all stages of CKD in these dogs and an increase in tubulointerstitial injury towards the end-stage of the disease. The results of the present study support the recommendation of SDS-PAGE as an effective technique for the qualitative assessment of proteinuria, as well as a method for assessing the severity and location of renal injury.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1590/1678-4162-11146