Peer-reviewed veterinary case report
High fructosamine levels in two dogs caused by IgA protein disorder
By Zeugswetter, Florian et al.·Published in Journal of veterinary science·2010·Department of Companion Animals and Horses·View original on PubMed →
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Original publication title: Elevated fructosamine concentrations caused by IgA paraproteinemia in two dogs.
- Species:
- dog
Plain-English summary
An 8-year-old male Austrian Pinscher and a 14-year-old male Golden Retriever were brought to the vet because they had unusually high fructosamine levels, which is a marker often associated with diabetes, but their blood sugar levels were normal. The Pinscher also had nosebleeds, while the Golden Retriever was drinking and urinating more than usual. Tests showed that both dogs had a condition called multiple myeloma, which is a type of cancer affecting blood cells. After diagnosis, the dogs were monitored, and the findings suggest that high fructosamine levels can sometimes indicate this serious condition rather than diabetes.
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Abstract
An 8-year-old male Austrian Pinscher and a 14-year-old male Golden Retriever were presented for evaluation due to unexplainable high fructosamine values despite euglycemia and epistaxis in combination with polydipsia/polyuria, respectively. Blood analysis revealed severe hyperglobulinemia, hypoalbuminemia and markedly elevated fructosamine concentrations in both dogs. Multiple myeloma with IgA-monoclonal gammopathy was diagnosed by serum and urine electrophoresis including immunodetection with an anti-dog IgA antibody and bone marrow aspirations. Diabetes mellitus was excluded by repeated plasma and urine glucose measurements. Fructosamine values were positively correlated with globulin, but negatively correlated with albumin concentrations. These cases suggest that, as in human patients, monoclonal IgA gammopathy should be considered as a possible differential diagnosis for dogs with high fructosamine concentrations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21113108/