Peer-reviewed veterinary case report
High IL-12/IL-23p40 levels in Nova Scotia Duck Tolling Retrievers
By Nilsson, Malin et al.·Published in Scientific reports·2024·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma.
- Species:
- dog
Plain-English summary
A group of Nova Scotia Duck Tolling Retrievers (NSDTRs) with autoimmune diseases and lymphoma were found to have higher levels of certain immune system proteins (IL-12/IL-23p40) compared to healthy dogs. This suggests that these proteins may play a role in the development of these conditions. While the study did not find differences in another protein (IL-2) between healthy and sick dogs, the elevated levels of IL-12/IL-23p40 could help veterinarians understand and potentially treat these diseases better. If your NSDTR is showing symptoms of autoimmune disease or cancer, discussing these findings with your vet could be beneficial.
People also search for: NSDTR autoimmune disease symptoms · dog lymphoma treatment · elevated IL-12 in dogs
Abstract
The Nova Scotia Duck Tolling Retriever (NSDTR) is predisposed to immune mediated rheumatic disease (IMRD), steroid-responsive meningitis-arteritis (SRMA) and certain forms of cancer. Cytokines are the main regulators of the immune system. Interleukin 2 is a cytokine involved in activation of T regulatory cells, playing a role in central tolerance and tumor immunity. Interleukin 12 and interleukin 23 share the same subunit, p40, and are both pro-inflammatory cytokines. The aim of this study was to compare levels of IL-2 in healthy NSDTRs to those with cancer or autoimmune disease and to compare levels of IL-12/IL-23p40 in healthy NSDTRs and beagles versus NSDTRs with cancer or autoimmune disease. 62 dogs were included in the analysis of IL-12/IL-23p40; healthy NSDTRs (n = 16), healthy beagles (n = 16), NSDTRs autoimmune (n = 18) and NDSTRs lymphoma/mastocytoma (n = 12) and 68 dogs for IL-2; healthy (n = 20), autoimmune (n = 36) and lymphoma/mastocytoma/adenocarcinoma (n = 12). NSDTRs with autoimmune disease had higher levels of IL-12/IL-23p40 compared to healthy dogs (p = 0.008). NSDTRs with lymphoma also had higher levels of IL-12/IL-23p40 compared to healthy NSDTRs (p = 0.002). There was no difference in levels of IL-2 between healthy and diseased NSDTR. Statistical analysis was performed using Bonferroni corrections for multiple testing. These findings can contribute to the knowledge of autoimmune disease and cancer in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38773194/