Peer-reviewed veterinary case report
Emergency dialysis to treat amikacin overdose in a cat
By Mauro, Katie D et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2021·Department of Clinical Sciences & Advanced Medicine, United States·View original on PubMed →
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Original publication title: Emergency treatment with intermittent hemodialysis for amikacin overdose in a cat.
- Species:
- cat
Plain-English summary
A cat accidentally received a high dose of amikacin, a medication that can be toxic in large amounts. Four hours later, the cat underwent an emergency treatment called intermittent hemodialysis (IHD) to help remove the drug from its system. This treatment successfully lowered the amikacin levels in the cat's blood to a safe range. However, the cat did develop severe acute kidney injury as a result of the overdose, but after four days of supportive care, the kidney function improved and the cat was discharged healthy.
People also search for: cat amikacin overdose treatment · cat kidney injury recovery · emergency hemodialysis for cats
Abstract
OBJECTIVE: To describe the safety and use of intermittent hemodialysis (IHD) for the emergency treatment of a cat with an amikacin overdose. CASE SUMMARY: A cat was accidentally administered 400 mg (97.5 mg/kg, IV) of amikacin. Four hours after the time of the overdose, a single emergency IHD session to remove amikacin was performed. The 4-hour IHD treatment allowed for the active removal of approximately 110 mg of amikacin. The plasma concentration of amikacin from the beginning to the end of the session decreased from approximately 160 μg/mL to a nontoxic concentration of 10 μg/mL. Following IHD treatment, the cat developed an International Renal Interest Society (IRIS) grade IV acute kidney injury (AKI) with a peak creatinine of 486 μmol/L (5.5 mg/dL) and was hospitalized for 4 days for supportive management of AKI. At the time of discharge, 4 days following the overdose, the AKI had resolved. NEW OR UNIQUE INFORMATION PROVIDED: This is the first report describing the use and safety of using IHD for emergency removal of amikacin overdose in a cat.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34499808/